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Clinical indications

Heart indications

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  • Treatment of genuine heart insufficiency in patients who have proven to be failures with either drug when used alone or in combination.
  • Reduction of myocardial oxygen requirements during acute or chronic cardiac ischemia.
  • Reduction of risk of fatal cardiac arrhythmias in the immediate post- myocardial infarction period.

Diabetes indications

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  • Treatment of non-insulin dependent diabetes ( diabetes type 2 ) when the conditions cannot controlled adequately by diet and reduction of excess weight alone.
  • May be used concomitantly with other oral agents in patients who have proven to be failures with either drug when used alone or in combination.
  • May be used in combination with insulin to reduce the insulin dose where reduction of insulin dosage or frequency is considered beneficial.
  • As a adjunct therapy of diabetic ketoacidosis.

Other metablism diseases

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  • For reduction of triglycerides and LDL-cholesterol to prevent arteriosclerosis.

Rheumatoid arthritis and other inflammatory diseases

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  • Treatment alone or in combination with known anti-inflammatory drugs to prevent side-effects.

Leukemia and other cancer

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  • For enhancement of clinical efficacy of anti-tumor agents.

Farm animal ketosis

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  • Treatment of dairy cow ketoacidosis.