Clinical indications

Treatment of genuine heart insufficiency in patients who have proven to be failures with either drug when used alone or in combination.
Reduction of myocardial oxygen requirements during acute or chronic cardiac ischemia.
Reduction of risk of fatal cardiac arrhythmias in the immediate post- myocardial infarction period.

Treatment of non-insulin dependent diabetes ( diabetes type 2 ) when the conditions cannot controlled adequately by diet and reduction of excess weight alone.
May be used concomitantly with other oral agents in patients who have proven to be failures with either drug when used alone or in combination.
May be used in combination with insulin to reduce the insulin dose where reduction of insulin dosage or frequency is considered beneficial.
As a adjunct therapy of diabetic ketoacidosis.

Treatment alone or in combination with known anti-inflammatory drugs to prevent side-effects.